Publikationsliste Prof. Dr. med. Thomas Tüting
Ausgewählte Originalarbeiten in Zeitschriften mit Wissenschaftlichem Beirat


Ausgewählte Original- und Übersichtsarbeiten in Zeitschriften mit Wissenschaftlichem Beirat

2014

  • Bald T, Landsberg J, Lopez-Ramos D, Renn M, Glodde N, Jansen P, Gaffal E, Steitz J, Tolba R, Kalinke U, Limmer A, Jönsson G, Hölzel M, Tüting T. Immune-cell poor melanomas benefit from PD-1 blockade after targeted type I IFN activation. Cancer Discovery. In press, 2014. (IF 2012: 10,1).
 
  • Gaffal E, Cron M, Glodde N, Schröder R, Kostenis E, Tüting T. Beta-arrestin 2 inhibits proinflammatory chemokine production and attenuates contact allergic inflammation in the skin. J Invest Dermatol. In press, 2014. (IF 2012: 6,3).
 
  • Bald T, Quast T, Landsberg J, Rogava M, Glodde N, Lopez-Ramos D, Kohlmeyer J , Riesenberg,S. van den Boorn-Konijnenberg D, Hömig-Hölzel C, Reuten R, Schadow B, Weighardt I, Wenzel D, Helfrich I, Schadendorf D, Bloch W, Bianchi ME, Koch M, Fleischmann BK, Förster I, Kastenmüller W, Kolanus W, Hölzel M, Gaffal E, Tüting T. Ultraviolet radiation-induced inflammation promotes angiotropism and metastasis in melanoma. Nature 507:109-13, 2014.
 
2013
  • Gaffal E, Cron M, Glodde N, Tüting T. Anti-inflammatory activity of topical THC in DNFB-mediated mouse allergic contact dermatitis independent of CB1 and CB2 receptors. Allergy. 68:994-1000, 2013.
 
  • Gehrke N, Mertens C, Zillinger T, Wenzel J, Bald T, Zahn S, Tüting T, Hartmann G, Barchet W. Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing. Immunity. 39:482-95, 2013.
 
  • Zahn S, Graef M, Barchet W, Bieber T, Tüting T, Wenzel J. Nitrosative stress: a hallmark of the junctional inflammation in cutaneous lupus erythematosus. Clin Exp Dermatol. 38:96-7, 2013.
 
  • Gaffal E, Cron M, Glodde N, Bald T, Kuner R, Zimmer A, Lutz B, Tüting T. Cannabinoid 1 receptors in keratinocytes modulate proinflammatory chemokine secretion and attenuate contact allergic inflammation. J. Immunol. 190:4929-36, 2013.
 
2012
  • Landsberg J, Kohlmeyer J, Renn M, Bald T, Rogava M,   Cron M, Fatho M, Lennerz V, Wölfel T, Hölzel H, Tüting T . Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation. Nature. 490:412-416, 2012.
  • Hornung T, Ko A, Tüting T , Bieber T, Wenzel J. Efficacy of low-dose methotrexate in the treatment of dermatomyositis skin lesions. Clin Exp Dermatol. 37:139-42. 2012. (IF 2012: 1,3).
     
  • Tüting T. T cell immunotherapy for melanoma from bedside to bench to barn and back. Pigment Cell Melanoma Res. 26:441-56, 2013.
     
  • Hölzel M, Bovier A, Tüting T. Plasticity of tumour and immune cells: a source of heterogeneity and a cause for therapy resistance? Nat Rev Cancer. 13:365-76, 2013.

2011

  • Koch P, Breuer P, Peitz M, Jungverdorben J, Kesavan J, Poppe D, Doerr J, Ladewig J, Mertens J, Tüting T, Hoffmann P, Klockgether T, Evert BO, Wüllner U, Brüstle O. Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease. Nature
  • Gaffal E, Landsberg J, Bald T, Sporleder A, Kohlmeyer J, Tüting T. Neonatal UVB exposure accelerates melanoma growth and enhances distant metastases in Hgf-Cdk4(R24C) C57BL/6 mice. Int J Cancer
  • Hangalapura BN, Oosterhoff D, Gupta T, de Groot J, Wijnands PG, van Beusechem VW, den Haan J, Tüting T, van den Eertwegh AJ, Curiel DT, Scheper RJ, de Gruijl TD. Delivery route, MyD88 signaling and cross-priming events determine the anti-tumor efficacy of an adenovirus based melanoma vaccine. Vaccine
  • Bilkei-Gorzo A, Drews E, Albayram O, Piyanova A, Gaffal E, Tueting T, Michel K, Mauer D, Maier W, Zimmer A. Early onset of aging-like changes is restricted to cognitive abilities and skin structure in Cnr1(-/-) mice. Neurobiol Aging
  • Zahn S, Rehkämper C, Kümmerer BM, Ferring-Schmidt S, Bieber T, Tüting T, Wenzel J. Evidence for a Pathophysiological Role of Keratinocyte-derived Type III interferon (IFNλ) in cutaneous lupus erythematosus. J Invest Dermatol

2010
  • Landsberg J, Gaffal E, Cron M, Kohlmeyer J, Renn M, Tüting T. Autochthonous primary and metastatic melanomas in Hgf-Cdk4R24C mice evade T-cell-mediated immune surveillance. Pigment Cell Melanoma Res
  • Osen W, Soltek S, Song M, Leuchs B, Steitz J, Tüting T, Eichmüller SB, Nguyen XD, Schadendorf D, Paschen A. Screening of Human Tumor Antigens for CD4 T Cell Epitopes by Combination of HLA-Transgenic Mice, Recombinant Adenovirus and Antigen Peptide Libraries. PLoS One.
  • Backer R, Schwandt T, Greuter M, Oosting M, Jüngerkes F, Tüting T, Boon L, O'Toole T, Kraal G, Limmer A, den Haan JM. Effective collaboration between marginal metallophilic macrophages and CD8+ dendritic cells in the generation of cytotoxic T cells. PNAS
  • Eberle J, Spangler B, Becker JC, Heinemann SH, Klein CA, Kunz M, Kuphal S, Langer P, Mauch C, Meierjohann S, Paschen A, Schadendorf D, Schartl M, Schittek B, Schönherr R, Tüting T, Zigrino P, Bosserhoff AK; German Melanoma Research Network of the German Cancer Aid. Multicentre study on standardisation of melanoma cell culture--an initiative of the German Melanoma Research Network. Pigment Cell Melanoma Res.
  • Stabenow D, Frings M, Trück C, Gärtner K, Förster I, Kurts C, Tüting T, Odenthal M, Dienes HP, Cederbrant K, Protzer U, Knolle PA. Bioluminescence imaging allows measuring CD8 T cell function in the liver. Hepatology
  • Petrosino S, Cristino L, Karsak M, Gaffal E, Ueda N, Tüting T, Bisogno T, De Filippis D, D'Amico A, Saturnino C, Orlando P, Zimmer A, Iuvone T, Di Marzo V. Protective role of palmitoylethanolamide in contact allergic dermatitis. Allergy

2009
  • Ney JT, Schmidt T, Kurts C, Zhou Q, Eckert D, Felsher DW, Schorle H, Knolle P, Tüting T, Barchet W, Büttner R, Limmer A, Gütgemann I. Autochthonous liver tumors induce systemic T cell tolerance associated with T cell receptor down-modulation. Hepatology
  • Kohlmeyer J, Cron M, Landsberg J, Bald T, Renn M, Mikus S, Bondong S, Wikasari D, Gaffal E, Hartmann G, Tüting T. Complete regression of advanced primary and metastatic mouse melanomas following combination chemoimmunotherapy. Cancer Res
  • Tormo D, Checińska A, Alonso-Curbelo D, Pérez-Guijarro E, Cañón E, Riveiro-Falkenbach E, Calvo TG, Larribere L, Megías D, Mulero F, Piris MA, Dash R, Barral PM, Rodríguez-Peralto JL, Ortiz-Romero P, Tüting T, Fisher PB, Soengas MS. Targeting activation of innate immunity for therapeutic induction of autophagy and apoptosis in melanoma cells. Cancer Cell

2008
  • Wenzel J, Peters B, Zahn S, Birth M, Hofmann K, Küsters D, Tomiuk S, Baron JM, Merk HF, Mauch C, Krieg T, Bieber T, Tüting T, Bosio A. Gene expression profiling of lichen planus reflects CXCL9+-mediated inflammation and distinguishes this disease from atopic dermatitis and psoriasis. J Invest Dermatol
  • Betz RC, König K, Flaquer A, Redler S, Eigelshoven S, Kortüm AK, Hanneken S, Hillmer A, Tüting T, Lambert J, De Weert J, Kruse R, Lutz G, Blaumeiser B, Nöthen MM. The R620W polymorphism in PTPN22 confers general susceptibility for the development of alopecia areata. Br J Dermatol
  • *Poeck H, *Besch R, *Maihoefer C, *Renn M (*contributed equally), Tormo D, Shulga Morskaya S, Kirschnek S, Gaffal E, Landsberg J, Hellmuth J, Schmidt A, Anz D, Bscheider M, Schwerd T, Berking C, Bourquin C, Kalinke U, Kremmer E, Kato H, Akira S, Meyer R, Häcker G, Neuenhahn M, Busch D, Ruland J, Rothenfusser S, Prinz M, Hornung V, Endres S, #Tüting T, #Hartmann G (#corresponding authors). 5'-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma. Nature Medicine

2007
  • *Karsak M, *Gaffal E, Date R, Wang-Eckhardt L, Rehnelt J, Petrosino S, Starowicz K, Steuder R, Schlicker E, Cravatt B, Mechoulam R, Buettner R, Werner S, Di Marzo V, #Tüting T, #Zimmer A (#corresponding authors). Attenuation of allergic contact dermatitis through the endocannabinoid system. Science
  • Gaffal E, Schweichel D, Tormo D, Steitz J, Lenz J, Basner-Tschakarjan E, Limmer A, Tüting T. Comparative evaluation of CD8+ CTL responses following gene gun immunization targeting the skin with intracutaneous injection of antigen-transduced dendritic cells. Eur J Cell Biol 86:817-26, 2007.
  • Wenzel J, Proelss J,Wiechert A, Zahn S, Bieber T, Tüting T. CXCR3-mediated recruitment of cytotoxic lymphocytes in lupus erythematosus profundus. J Am Acad Dermatol
  • Wenzel J, Zahn S, Mikus S, Wiechert A, Bieber T, Tüting T. The expression pattern of IFN-inducible proteins reflects the characteristic histological distribution of infiltrating immune cells in different cutaneous lupus erythematosus subsets. Brit J Dermatol

2006
  • Steitz J, Tormo D, Ferrer A, Wenzel J, Büchs S, Huber C, Wölfel T, Barbacid M, Malumbres M, Tüting T. Evaluation of genetic melanoma vaccines in cdk4 mutant mice provide evidence for peripheral tolerance. Int J Cancer .
  • Steitz J, Britten C, Wölfel T, Tüting T. Effective induction of anti-melanoma immunity following genetic vaccination with synthetic mRNA coding for the fusion protein EGFP.TRP2. Cancer Immunol Immunother .
  • Reinhardt MJ, Joe AY, Jaeger U, Huber A, Matthies A, Bucerius J, Roedel R, Strunk H, Bieber T, Biersack HJ, Tüting T. Diagnostic Performance of Whole Body Dual Modality 18F-FDG PET/CT Imaging for N- and M-Staging of Malignant Melanoma: Experience With 250 Consecutive Patients. J Clin Oncol.
  • Steitz J, Tormo D, Schweichel D, Tüting T. Comparison of recombinant adenovirus and synthetic peptide for DC-based melanoma vaccination. Cancer Gene Ther
  • Wenzel J, Schmidt R, Prölss J, Zahn S, Bieber T, Tüting T. Typ I IFN-associated skin recruitment of CXCR3+ in dermatomyositis. Clin Exp Dermatol
  • Tormo D, Ferrer A, Bosch P, Gaffal E, Basner-Tschakarjan E, Wenzel J, Tüting T. Therapeutic efficacy of antigen-specific vaccination and toll-like receptor stimulation against established transplanted and autochthonous melanoma in mice. Cancer Res .
  • Tormo D, Ferrer A, Gaffal E, Wenzel J, Steitz J, Heukamp LC, Gütgemann I, Buettner R, Barbacid M, Malumbres M, Merlino G, Tüting T. Rapid growth of invasive metastatic melanoma in carcinogen-treated HGF/SF-transgenic mice carrying an oncogenic CDK4 mutation. Am J Pathol .
  • Wenzel J, Scheler S, Prölss J, Bieber T, Tueting T. Type I Interferon associated cytotoxic inflammation in Lichen ruber planus. J Cutan Pathol
  • Schweichel D, Steitz J, Tormo D, Gaffal E, Ferrer A, Büchs S, Speuser P, Limmer A, Tüting T. Evaluation of DNA vaccination with recombinant adenoviruses using bioluminescence imaging of antigen expression: Impact of application routes and delivery with dendritic cells. J Gene Med .
  • Basner-Tschakarjan E, Gaffal E, O’Keeffe M, Tormo D, Limmer A, Wagner H, Hochrein H, Tüting T. Adenovirus efficiently transduces plasmacytoid dendritic cells resulting in TLR9-dependent maturation and IFNa production. J Gene Med.