Durchgeführte Studien

Randomised Controlled Trials
Phase
Identifier
MANAGE (Management of myocardial injury After NoncArdiac surGEry) - A large, international, randomized, placebo-controlled trial to assess the impact of dabigatran (a direct thrombin inhibitor) and omeprazole (a proton-pump inhibitor) in patients suffering myocardial injury after noncardiac surgery
3
2011-006056-37 / NCT01661101
POISE-2 ( PeriOperative ISchemic Evaluation-2) : A large, international, placebo-controlled, factorial trial to assess the impact of clonidine and acetyl-salicylic acid (ASA) in patients undergoing noncardiac surgery who are at risk of a perioperative cardiovascular event
3
2009-18173-31 / NCT01082874
OXN2505: An exploratory, double-blind, double-dummy, randomised, 2-period, crossover, Phase IIa study to assess the influence of oxycodone/naloxone prolonged-release tablets (OXN PR) and oxycodone prolonged-release tablets (OxyPR) on intestinal microbiota and other gastrointestinal parameters in subjects suffering from non-malignant pain requiring an equivalent of 20 – 50 mg oxycodone PR per day
 2a
2012-001772-11 / NCT01915147
 
NCT01441791
MDCO-2010 - A Phase II, double-blind, parallel group, dose-selection study to compare antifibrinolytic MDCO-2010 vs. placebo and tranexamic acid in reducing blood loss in patients undergoing primary cardiac surgery.
 2b
 2011-004666-15 / NCT01530399
VNK115640 - A Multicenter, Randomized, Single-blind, Active-controlled, Parallel Group, Phase II Study to Evaluate the Efficacy, Safety, and Tolerability of a Single Intravenous (6 mg, 12 mg, 18 mg, 24 mg or 36 mg) Dose of the Neurokinin-1 Receptor Antagonist, Vestipitant (GW597599), Compared with a Single 4 mg Intravenous Ondansetron Hydrochloride Dose for the Treatment of Breakthrough Post-Operative Nausea and Vomiting after Failed Prophylaxis with an Ondansetron-
2
2011-005216-28 / NCT01507194
Containing Regimen in Patients Undergoing Non-Emergency Surgical Procedures.
Sugammadex - Reversal of neuromuscular blockade with sugammadex or usual care in hip/knee fracture surgery or joint replacement
 3
 2011-001201-27 / NCT01422304
RIPHeart Study ( Remote Ischaemic Preconditioning for Heart surgery) - The study design for a multi-center randomized double-blinded controlled clinical trial
 3
DFG: ME3559/1 / NCT01067703
Sunlight - A randomized, safety-assessor blinded trial comparing 4.0 mg.kg-1 sugammadex with placebo in adult subjects scheduled for surgery requiring profound neuromuscular blockade
 3
2008-002518-23 / NCT00758485
 2
 2008-008354-23 / NCT00888940
 2
 2006-006034-18 / NCT00157716
A Double-Blind Multicenter Study of the Safety and Efficacy of Parecoxib Sodium/Valdecoxib and Placebo/Valdecoxib Compared to Placebo for Treatment of Post-Surgical Pain in Patients Who Have Coronary Bypass Graft Via Median Sternotomy
3
 NCT00636064
 3
  2008-00488-16 / NCT00872001
E5564 - A multicenter, randomized, double-blind, placebo-controlled, parallel study of E5564, a lipid antagonist, in patients undergoing coronary artery bypass grafting and/or valve surgery with cardiopulmonary bypass
 3
  E5564-A001-204
 4
 
 3
 Protocol NTL06
 3
HOE642A/3002

 

Observatory Studies
Identifier
POPULAR (POstaneasthesia PULmonary complications After use of muscle Relaxants in europe)
NCT: 01865513
ISOS (International Surgical Outcomes
Study) - An international observational cohort study of complications following elective surgery
 
BONNCORE (BONN Cerebral Oxygen Risk Evaluation) -Präoperative Risikoevaluation: Stellenwert der zerebralen Oxygenierung bei nicht.kardiochirurgischen Patienten mit schwerer Allgemeinerkrankung
 
ETPOS (European Transfusion Practice and Outcome Study) - A Multi-central evaluation of standard of transfusion care and clinical outcome for elective surgical patients - observational
NCT01604083
EMMAperiop (Evaluation des Managements von ambulanten Medikamenten für die Anästhesie in der perioperativen) -Prospektive multizentrische Beobachtungsstudie des Effekts des perioperativen Managements von RAAS Modulatoren vor elektiven operativen Eingriffen.
 
OBTAIN (Occurrence of Bleeding and Thrombosis during Antiplatelet therapy in Non-cardiac surgery) - A prospective oberservational study
NCT01358422 
PERISCOPE (Prospective Evaluation of a RIsk Score for postoperative pulmonary COmPlications in Europe) - multi-centre, international observational study of a random-sample cohort of patients undergoing a nonobstetric in-hospital surgical procedure under general or regional anaesthesia during a continued 7-day period of recruitment
NCT01346709
EuSOS (European Surgical Outcomes Study) - multi-centre, international cohort study of peri-operative care and clinical outcomes for patients undergoing non-cardiac surgery
NCT01203605
Euro-STAT (European registry for Studying the Treatment of Acute hyperTension) -  Characteristics, practice patterns, and outcomes in patients with acute hypertension
 
A controlled, prospective, observational cohort study to examine the technique of opioid rotation to oral sustained-release hydromorphone for controlling pain and symptoms in outpatients with cancer pain
 
PBM (Patient Blood Management) - Safety and Effectiveness of a Patient Blood Management Program in Surgical Patients - prospective observational
NCT01820949